Love my Harmony One; had to update the inputs since I rewired my TV, so tried getting the latest software, all fine and dandy until...
Remote is now bricked! Goes straight into safe mode! Tried some things from the web: Drain battery, take out, wait a day and install, press OK while booting, press '2' while booting... Nothing.
I guess I had to reflash... Took me days to find the info, as using the provided software automatically updated to the new version, which keeps bricking the remote (goes into Safe mode always)!
Until I found: This is the website where you can reflash the firmware!
So happy my remote's back!